Studies of remote control storage for semantic information and Thiazovivin concepts claim that hippocampal lesions result in a temporally graded impairment that extends only ten years Thiazovivin before the starting point of amnesia. stories and bible tales that they graded as familiar. Narratives had been scored for amount and kind of information amount of primary thematic components and order where the primary thematic components were recounted. Compared to handles sufferers with MTL lesions created fewer information but the amount and purchase of primary thematic components generated was unchanged. By contrast sufferers with MTL+ lesions demonstrated a pervasive impairment affecting not only the generation of details but also the generation Thiazovivin and ordering of main steps. These findings challenge the notion that once consolidated semantic memories are no longer dependent on the hippocampus for retrieval. Possible hippocampal contributions to the retrieval of detailed semantic narratives are discussed. =.035 η2=.17] and a main effect of type of accurate detail [<. 001 η2=.65]. The group x detail type interaction was marginal [=.099 η2=.05]. Figure 2 Mean number of accurate details of each type generated by controls (white bars) the whole amnesic patient group (black bars) amnesic patients with lesions restricted to the MTL (dark grey bars) and amnesic patients with lesions extending into anterolateral ... The two patients with MTL+ lesions provided the lowest number of accurate details. To evaluate whether the impairment in the amnesic group was due solely to the inclusion of the MTL+ patients we performed an additional analysis comparing only patients with MTL lesions to controls. The main effect of group was not significant [< .001 η2=.84] was modified by a group x detail type interaction [=.034 η2=.02]. Post hoc comparisons indicated that the MTL patients were impaired in generating event place and time details [=.26 =.021 < 1 < .01 = Thiazovivin .06 < 1 d=.26). Follow-up analyses using a modified t-test for single cases (Crawford & Howell 1998 indicated that there was no Thiazovivin evidence for impaired recognition in any of the MTL patients [t’s < 1.05 p’s > .30 d’s<.48]. However the two MTL+ patients performed more poorly than controls [t’s > 2.37 p’s Thiazovivin < .01 d’s>1.09]. Table 3 Mean Proportion (and SEM) of Targets (Hits) and False Details (FAs) Endorsed by Controls and Amnesic Patients as well as Corrected Recognition Performance (Hits-FAs). 4 Discussion The results of this study are consistent with those of Moscovitch and Melo (1997) and Rosenbaum and colleagues (Rosenbaum et al. 2009 in that they demonstrate that patients with amnesia are impaired in their ability to recount detailed semantic narratives. Our findings go beyond these previous studies however in that they elucidate the contribution of both MTL and anterolateral temporal regions to memory MGC57564 for semantic narratives. Patients with lesions restricted to the MTL produced narratives that were reduced in amount of detail but they had preserved schematic representations of the stories as indexed by the fact that their narratives included a similar number of thematic elements as those of controls. Further even though recall of narrative details was impoverished recognition of such details was intact. These results suggest that lesions of the MTL do not result in loss of knowledge about premorbidly acquired semantic narratives but rather interfere with the ability to recover that knowledge in rich detail. In contrast patients with lesions extending into anterolateral temporal neocortex had a pervasive impairment in memory for semantic narratives. This impairment was apparent not only in their difficulty retrieving story details but also in their impoverished access to schematic representations and their inability to distinguish true from false story details. These findings accord well with the notion that the anterior and lateral temporal lobes are the critical storage sites for semantic memories (Hodges 2003 Rogers et al. 2004 Saffran & Schwartz 1994 Hodges 2003 Saffran & Schwartz 1994 Lesions affecting these regions lead to a degradation of semantic knowledge that manifests regardless of method of.