Quickly growing tumor cells must synthesize proteins at a high rate and consequently depend about an efficient folding and quality control system for nascent secretory proteins in the endoplasmic reticulum (ER). the Deutsche Forschungsgemeinschaft Study Teaching Group 1739 (GRK1739). The writers are pleased to Bert Vogelstein, Howard Hughes Medical Company, Baltimore, Baltimore, for supply of HCT116 p53?/? cells. The writers are indebted to George Iliakis significantly, Institut fr Strahlenbiologie, Universit?testosterone levels Duisburg-Essen, for building all light apparatus obtainable to us. Verena Jendrossek, Institut fr Zellbiologie, Universit?testosterone levels Duisburg-Essen, is acknowledged for writing reagents and for helpful conversations. The writers give thanks to Harald Engler also, Institut fr Medizinische Psychologie, Universit?testosterone levels Duisburg-Essen, for help with the FACS analysis. 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