Supplementary Materials1. presented using CRISPR-cas9 nickase into two prostate cancers cell lines, LAPC-4 (produced from a lymph node metastasis) and CWR22Rv1 (sourced from a xenograft set up from an initial prostate cancers). In LAPC-4, however, not CWR22Rv1, abolishing ATRX was enough to induce multiple ALT-associated hallmarks, like the existence of ALT-associated PML systems (APBs), extrachromosomal… Continue reading Supplementary Materials1