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Supplementary Materialscancers-12-01646-s001. elevated hepatoma cell proliferation, xenograft and migration growth. Downstream effectors researched by cDNA microarray evaluation discovered UHMK1, an oncogenic proteins, which manifested a correlated expression degree of COX5B positively. The COX5B-mediated regulatory event on UHMK1 expression was demonstrated as bioenergetic alteration-dependent activation of AMPK in hepatoma cells subsequently. Phosphoproteomic evaluation uncovered activation of

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