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A large-scale synthesis of conformation from the vicinal difluoride moiety. difluoride moieties straightforward isn’t. Direct methods consist of fluorination of alkenes with F2 [19], XeF2 [20], or hypervalent iodine types [21]. Such approaches display poor stereoselectivity or bring about rearrangement products frequently. Treatment of just one 1,2-diols with SF4 [22C23], DAST [24], or deoxofluor [25]

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