Combined MAPK/PI3K pathway inhibition signifies a nice-looking, albeit poisonous, therapeutic strategy in oncology. PTEN-loss contexts and determined JAK1/STAT3 activation like a 950769-58-1 manufacture potential mediator of synergistic relationships. Overall, our outcomes display that PTEN-loss can be an essential determinant of synergistic relationships between PI3K and MAPK pathway inhibitors, possibly exploitable for selecting cancer individuals at… Continue reading Combined MAPK/PI3K pathway inhibition signifies a nice-looking, albeit poisonous, therapeutic strategy