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EWS/FLI is a professional regulator of Ewing’s sarcoma formation. to mediate the repressive function of NKX2.2, inhibited the transformed phenotype and reversed the NKX2.2 transcriptional profile in Ewing’s sarcoma cells. Entire genome localization research (ChIP-chip) revealed a significant part of the NKX2.2-repressed gene expression signature was mediated by NKX2.2 binding. These data show which the

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