Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson’s disease and other synucleinopathies. or affect the transportation of mitochondria or synaptophysin. Nevertheless the α-syn aggregates impair the transport of TrkB and Rab7 receptor-containing endosomes aswell as autophagosomes. Furthermore the TrkB receptor-associated signaling molecule benefit5 accumulates in α-syn aggregate-bearing neurons. Α-syn pathology impairs axonal transport of… Continue reading Aggregates of α-synuclein (α-syn) accumulate in neurons in Parkinson’s disease and