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Longevity and deposition of multiple context-dependent signaling pathways of long-standing irritation (antigen-load or oxidative tension) will be the outcomes of decreased/altered legislation of immunity and lack of control change mechanisms that people thought as Yin and Yang of acute irritation or immune security. minor (e.g., elevated allergy symptoms), moderate (e.g., hypertension, colitis, gastritis, pancreatitis, emphysema)

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