Repulsive guidance molecule (RGM) is usually a membrane-bound protein that was

Repulsive guidance molecule (RGM) is usually a membrane-bound protein that was originally identified as an axon guidance molecule in the chick retinotectal system. we propose that this peptide is usually a promising lead in finding reagents capable of inhibiting RGMa signaling. Introduction Repulsive guidance molecule (RGM) is usually a cell membrane-associated glycosylphosphatidylinositol (GPI)-anchored glycoprotein that… Continue reading Repulsive guidance molecule (RGM) is usually a membrane-bound protein that was

Presenilin is the catalytic element of the γ-secretase organic a membrane-embedded

Presenilin is the catalytic element of the γ-secretase organic a membrane-embedded aspartyl protease that has a central function in biology and in the pathogenesis of Alzheimer’s disease. homologs and small-molecule inhibitors and cysteine checking with crosslinking possess suggested specific presenilin residues and locations that donate to substrate reputation and handling. Id of incomplete complexes in… Continue reading Presenilin is the catalytic element of the γ-secretase organic a membrane-embedded