Enzymes embedded into the RNA editing core complex (RECC) catalyze the U-insertion/deletion editing cascade to generate open reading frames in trypanosomal mitochondrial mRNAs. Although both gRNAs and mRNAs are associated with the RESC their metabolic fates are unique: gRNAs are degraded in an editing-dependent process whereas edited mRNAs undergo 3′ adenylation/uridylation prior to translation. Our… Continue reading Enzymes embedded into the RNA editing core complex (RECC) catalyze the