Estrogen receptor (ER) binds to distal enhancers inside the genome and requires additional factors such as the Forkhead protein FoxA1 for mediating chromatin interactions. malignancy therapies including tamoxifen and aromatase inhibitors (2). Understanding how estrogen-ER initiates transcription events is usually paramount in BINA understanding how endocrine therapies work and what happens if they fail. ER… Continue reading Estrogen receptor (ER) binds to distal enhancers inside the genome and