Heterotrimeric G proteins are quintessential signalling switches turned on by nucleotide exchange about G. intracellular effectors and regulate a huge selection of physiological procedures1,2. G-protein activation can be accomplished when GDP can be exchanged for GTP for the G subunit, a response catalysed by guanine-nucleotide exchange elements (GEFs)3. G-protein-coupled receptors (GPCRs) will be the archetypical… Continue reading Heterotrimeric G proteins are quintessential signalling switches turned on by nucleotide