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Supplementary MaterialsSupplemental Figures 41419_2018_850_MOESM1_ESM. of APoptosis (cIAPs) ubiquitin ligases exerted a competent two times brake on apoptosis signaling. On the other hand, releasing only 1 of the two brakes was adequate to overcome the level of resistance of 8/8 tumor cell lines tested. Remarkably, the release of the c-FLIP, but not cIAPs, brake only results

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