The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell

The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell lymphoma (MCL) cells, and is believed to be associated with the pathogenesis of this disease. to influence patient survival in MCL, and the SINE XPO1 antagonist KPT-185 effectively activates p53-mediated transcription and apoptosis, which would provide a novel strategy for the therapy of MCL.… Continue reading The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell