The prion protein (PrP) has been implicated both in prion diseases such as Creutzfeldt-Jakob disease where its monomeric cellular isoform (PrPC) is recruited into pathogenic self-propagating polymers of misfolded protein and in Alzheimer disease where PrPC may act as a receptor for synaptotoxic oligomeric forms of amyloid-β (Aβ). challenging and the highly heterogeneous nature of… Continue reading The prion protein (PrP) has been implicated both in prion diseases