Dissection of regulatory systems that control gene transcription is among the

Dissection of regulatory systems that control gene transcription is among the greatest problems of functional genomics. Each such set indicates useful co-operation between its people in regulating the transcriptional program associated with cell cycle progression. The methods presented here are general and can be applied to the analysis of transcriptional networks controlling any biological process.… Continue reading Dissection of regulatory systems that control gene transcription is among the

The availability and robustness of solutions to analyze phosphorylated proteins has

The availability and robustness of solutions to analyze phosphorylated proteins has greatly expanded our understanding of phosphorylation-based cell signaling. each was aimed against acetylated lysine in various contexts. Using high res Fourier transform GW-786034 mass spectrometry we noticed that most acetylated lysine residues determined using the monoclonal antibody cocktail had been specific from those enriched… Continue reading The availability and robustness of solutions to analyze phosphorylated proteins has

The guidelines that govern memory T cell differentiation are not well

The guidelines that govern memory T cell differentiation are not well understood. program that does not require further antigenic stimulation and does not cease until memory CD8+ T cell formation. The main features that provide antigen-specific memory CD8+ T cells with a protective advantage over na?ve CD8+ T cells are that memory CD8+ T cells… Continue reading The guidelines that govern memory T cell differentiation are not well