By phosphorylating adverse elongation factors as well as the C-terminal domain of RNA polymerase II (RNAPII) positive transcription elongation element b (P-TEFb) which comprises CycT1 or CycT2 and CDK9 activates eukaryotic transcription elongation. which occurred just from an unannotated proximal promoter. ChIP with sequencing BI6727 (Volasertib) exposed P-TEFb-sensitive poised RNA polymerase II as of this… Continue reading By phosphorylating adverse elongation factors as well as the C-terminal domain