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The pharmacokinetics of apremilast and its own main metabolite M12 were evaluated in subject matter with varying examples of renal impairment. however, not in people that have gentle to moderate renal impairment. .9999116.5 (89.3C151.9)120.4 (92.2C157.2)Moderate renal impairmentImpaired, apremilast 30 mg (n = 8)3993.5 (51.7)197.2 (41.9)3.50 (0.5C8.0)11.12 (35.6)10.31 (70.2)144.31 (51.8)Healthy matched, apremilast 30 mg (n =

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