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Cardiac glycosides have already been used for the treating heart failure for their capabilities of inhibiting Na+/K+ ATPase (NKA), which boosts [Na+]we and attenuates Ca2+ extrusion the Na+/Ca2+ exchanger (NCX), leading to [Ca2+]we elevation. Na+/Ca2+ exchanger, however, not improving of Ca2+ uniporter, alleviated the undesireable effects of NKA inhibition. Oligomycin A Intriguingly, NKA inhibition elicited

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