Metabotropic Glutamate Receptors , 0 Comments

Aberrant pyroglutamate formation on the N terminus of specific peptides and protein, catalyzed by glutaminyl cyclases (QCs), is normally associated with some pathological conditions, such as for example Alzheimer disease. We also describe the high-resolution buildings of secretory QC (sQC)-PBD150 complicated and two various other gQC-inhibitor complexes. gQC framework includes a scaffold identical compared to

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