Transcriptional activation is definitely a key link between neuronal activity and long-term synaptic plasticity. requires convergent activation of the CaM kinase and MAP kinase pathways. Although activation of PKA is not required for activity-dependent manifestation is definitely induced by cAMP in active neurons. CREB binds the promoter in vivo and partially regulates its activity-dependent manifestation.… Continue reading Transcriptional activation is definitely a key link between neuronal activity and