Several germline single nucleotide polymorphisms (SNPs) have been identified in the gene, but little is known about their cellular and biochemical impact. rate than WT, although P242R binds DNA similarly to WT. Our results suggest that people who carry the rs3136797 germline SNP may be at an increased risk for cancer susceptibility. Author Summary Cancer… Continue reading Several germline single nucleotide polymorphisms (SNPs) have been identified in the