Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC)

Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) are predictive of response to treatment with tyrosine kinase inhibitors. Sequencing recognized rare mutations that are not identified by either castPCR or Therascreen, but in samples with low tumor cell content it failed to detect common mutations that were revealed by real-time PCR based… Continue reading Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC)

T-cell costimulatory molecules deliver positive or harmful indicators to govern the

T-cell costimulatory molecules deliver positive or harmful indicators to govern the best destiny of immune system replies. B7-H1, PD-1 and B7x have been observed to be expressed on tumor cells or infiltrating lymphocytes and are individually associated with adverse pathologic features and poor clinical end result. In prostate malignancy, B7-H3 and B7x immunostaining intensity correlate… Continue reading T-cell costimulatory molecules deliver positive or harmful indicators to govern the