Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac stress response including cardiomyocyte hypertrophy. from caveolae-enriched lipid raft microdomains at different levels; sGCβ1 at 4wkMR accompanied by sGCα1 at 12moMR. Appearance of both sGC subunits fell in 12moMR moreover. Using the heme-dependent NO donor DEA/NO and NO-/heme-independent sGC activator BAY 60-2770 we motivated… Continue reading Nitric oxide activation of soluble guanylyl cyclase (sGC) blunts the cardiac