Extreme production of endothelin-1 (ET-1), a powerful vasoconstrictor, occurs with many

Extreme production of endothelin-1 (ET-1), a powerful vasoconstrictor, occurs with many types of pulmonary hypertension. cultured rat PASMCs as well as the pH-sensitive dye, BCECF-AM, to measure adjustments in basal pHi and NHE activity induced by raising concentrations of ET-1 (10?10 to 10?8 M). We discovered that program of exogenous ET-1 elevated pHi 16830-15-2 IC50… Continue reading Extreme production of endothelin-1 (ET-1), a powerful vasoconstrictor, occurs with many