KOR activation of G reliant signaling leads to analgesia, whereas the dysphoric ramifications of KOR agonists are mediated by way of a different pathway involving G proteins receptor kinase and nonvisual arrestin. hKOR and rKOR. Likewise, butorphanol improved phospho-p38-ir in hKOR-expressing cells but didn’t activate p38 in rKOR-HEK293. Like pentazocine, butorphanol was similarly efficacious at… Continue reading KOR activation of G reliant signaling leads to analgesia, whereas the