Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. somatic mutation in pre-miR-146a/C. Collectively our outcomes reveal a central role for miR-146a in the initiation and progression of melanoma. DOI: http://dx.doi.org/10.7554/eLife.01460.001 in melanoma cell lines SKMEL-28 and M14 substantially decreased miR-146a levels and the expression of various other MYC focus on genes (Figure… Continue reading Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas.