A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements

A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements involving the Anaplastic Lymphoma Kinase (ALK) gene. to up-regulation of ESRP1 and E-cadherin, thus reverting the phenotype from mesenchymal to epithelial (MET). Consistently, ESRP1 knock-down impaired E-cadherin up-regulation upon ALK inhibition, whereas enforced expression of ESRP1 was sufficient to increase E-cadherin expression. These findings… Continue reading A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements