Supplementary MaterialsTransparent reporting form. as a ratio of red to green

Supplementary MaterialsTransparent reporting form. as a ratio of red to green fluorescence intensity. Compared to age-matched WT/Het siblings, mutants exhibited significantly lower JC-1 fluorescence ratios, indicating that the mitochondria are depolarized (Figure 2C) (WT/Het: 0.25??0.24 n?=?8 fish, Mutant: 0.05??0.07 n?=?8 fish, Mann-Whitney U test, p? ?0.01, mean ratio??SD). These results suggest that mitochondrial activity is… Continue reading Supplementary MaterialsTransparent reporting form. as a ratio of red to green

Anaplastic lymphoma kinase (ALK) gene activation is usually mixed up in

Anaplastic lymphoma kinase (ALK) gene activation is usually mixed up in carcinogenesis procedure for many human cancers such as for example anaplastic huge cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, because of fusion with additional oncogenes (NPM, EML4, TIM, etc) or gene amplification, mutation or protein overexpression. 2p23 chromosomal section and encodes for… Continue reading Anaplastic lymphoma kinase (ALK) gene activation is usually mixed up in