Background Conjugation from the ubiquitin-like modifier Nedd8 to cullins is crucial for the function of SCF-type ubiquitin ligases and therefore facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell routine regulators. defined as Yuh1 [18] (Uch1, Extra file 1: Amount S2). In the Yuh1 null mutant, there is absolutely no any neddylation… Continue reading Background Conjugation from the ubiquitin-like modifier Nedd8 to cullins is crucial
Tag: Staurosporine
The segregation of eukaryotic chromosomes during mitosis requires their extensive folding
The segregation of eukaryotic chromosomes during mitosis requires their extensive folding into units of manageable size for the mitotic spindle. S10 phosphorylation and deacetylation of histone H4 promote short-range compaction of chromatin during early anaphase. Independently condensin mediates the axial contraction of chromosome arms a process peaking later in anaphase. Whereas defects in chromatin compaction… Continue reading The segregation of eukaryotic chromosomes during mitosis requires their extensive folding
Venous thromboembolism (VTE) is usually a leading cause of death among
Venous thromboembolism (VTE) is usually a leading cause of death among outpatient chemotherapy patients. when heparin-based prevention was analyzed (OR 0.53; 95 % CI 0.41-0.70). We found strong prevention among individuals with lung malignancy (OR 0.46; 95 % CI 0.29-0.74) and pancreatic malignancy (OR 0.33; 95 % CI 0.16-0.67). Major bleeding events were frequent in… Continue reading Venous thromboembolism (VTE) is usually a leading cause of death among