Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, that have up to now not been investigated thoroughly for common oncogenic mutations. Knockdown of NRAS by siRNA induced apoptosis in mutant Hut78 cells however, not in CTCL cell lines missing RAS mutations. The NRASQ61K mutation sensitized Hut78 cells toward development inhibition from the MEK… Continue reading Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, that
Tag: TCS ERK 11e (VX-11e)
Antagonists of CXC chemokine receptor 4 (CXCR4) including AMD3100 induce peripheral
Antagonists of CXC chemokine receptor 4 (CXCR4) including AMD3100 induce peripheral mobilization of hematopoietic stem cells and have been approved for medical use. (BM) microenvironment [4]. SDF-1 only offers negligible effects within the proliferation of both normal and malignant hematopoietic cells TCS ERK 11e (VX-11e) [5] but the SDF-1/CXCR4 axis offers been shown to be… Continue reading Antagonists of CXC chemokine receptor 4 (CXCR4) including AMD3100 induce peripheral