Sodium reabsorption via the epithelial Na+ channel (ENaC) in the aldosterone-sensitive distal nephron takes on a central part in the rules of body fluid volume. 12 and 15-HETE but not 20-HETE. Single-channel patch-clamp experiments exposed that 8 9 14 15 and 11 12 all decrease ENaC activity. Neither 5- 12 nor 15-HETE experienced any effect… Continue reading Sodium reabsorption via the epithelial Na+ channel (ENaC) in the aldosterone-sensitive