The relationship between and the cognitive correlates of several proxy measures

The relationship between and the cognitive correlates of several proxy measures of functional status were studied in a population with moderate cognitive impairment (MCI). however both the informant-report IADL and the performance-based everyday problem-solving test correlated with the direct observation measure. After controlling for age and education cognitive predictors did not explain a significant amount of variance in the performance-based measures; however performance on a delayed memory task was a unique predictor for the informant-report IADL and processing speed predicted unique variance for the direct observation score. These findings indicate that differing methods for evaluating functional status are not assessing completely overlapping aspects of everyday functioning MK-3697 in the MCI population. 0.32 (percent female: MCI = 52.9% OAs = 62.7%). The OA control participants reported no history of cognitive change had a CDR score of 0 a TICS score ≥ 27 and a GDS-15 < 10. Because this study was conducted as part of a larger study (Schmitter-Edgecombe et al. 2011 the control group represented a subsample of the 168 healthy OAs who best demographically matched the MCI participants. Table 4 MK-3697 Demographic Data and Mean Summary Data for Healthy Older Adult and Mild Cognitive Impairment Groups In return for their time all participants were given a report documenting their performance around the neuropsychological assessments as well as pre-paid parking passes. Participants who traveled to the laboratory from outside Whitman or Latah counties were also provided travel reimbursement. This protocol was reviewed and approved by the Institutional Review Board at WSU. Measures Non-Cognitive MK-3697 Risk Factors Non-cognitive risk factors included participants’ age gender education Rabbit polyclonal to PLCB2. level and endorsement of depressive symptoms. The GDS-15 was used as the measure of depressive symptomology (total number of endorsed symptoms). Cognitive Variables The cognitive predictor variables were derived from performances on standardized neuropsychological assessments during a laboratory assessment. A brief description of each task as well as the score used for each cognitive predictor can be found in Table 2. The cognitive predictors represent five different cognitive domains that were found to predict functional status in prior studies (e.g. Farias et al. 2006 Mariani et MK-3697 al. 2008 including global cognitive status processing speed memory visuoperceptual abilities and executive functioning. Although the chosen cognitive MK-3697 predictors (i.e. neuropsychological assessments) are not “domain pure” they are most commonly associated with the identified cognitive domain. In addition for comparison purposes the cognitive predictors were identical to those used in a prior study with healthy OAs that examined cognitive correlates and functional abilities from middle-age through the old-old (Schmitter-Edgecombe et al.; 2011). Table 2 Description of Neuropsychological Assessments. Functional Status Measures The IADL domains assessed by the informant-report performance-based and direct observation measures were largely consistent (e.g. medication management meal preparation). For the purposes of this study we defined these proxy measures of real-world functioning as “functional status measures.” Knowledgeable Informant Report about Instrumental Activities of Daily Living (IADLs) A knowledgeable informant completed a 50-question interview about the participant’s ability to complete everyday activities (Schmitter-Edgecombe et al. 2012 The questions captured the following ten IADL domains: using the phone traveling shopping meal preparation household tasks conversation organization social functioning medication management and financial management. Each IADL question was rated using a Likert scale ranging from ‘1’ (impartial as well as ever no aid) to ‘8’ (not able to complete activity anymore). Answer choices for “no basis for judgment” or “does not need to complete the activity” were also options. A total score was derived as the average response of MK-3697 the answered questions. Forty-six informants of MCI participants and 38 informants of OA controls completed the interview.