A progressive decrease of rubella serology levels (IgG 264.6 UI/mL after one month) and a final level of 184 UI/mL in the second month of follow-up was noticed. == Discussion == Rubella is only found in humans and is transmitted via the respiratory tract. flu-like illness. His past medical history was unremarkable. Visual acuity was 20/200 in the right eye and 20/20 in the left eye. There was an afferent pupillary defect in the right TPOP146 eye. Biomicroscopic examination revealed fine keratic precipitates, trace anterior chamber cells, and 1+ anterior vitreous cells in the right eye. Examination of the left eye was normal. Intraocular pressure was 12 mmHg in both eyes. Fundus examination of the right eye showed a moderate vitreitis and posterior segment signs of a resolving neuroretinitis, characterized by diffuse retinal edema (macular star), retinal vasculitis, and moderate papillitis (Physique 1). The left eye fundus was unremarkable. Fluorescein angiogram confirmed these inflammatory signs in the right eye (Physique 1). Further workup for human immunodeficiency (HIV), venereal disease research laboratory (VDRL), cytomegalovirus (CMV), toxoplasmosis, tuberculosis, and herpes had negative results. A high erythrocyte sedimentation rate (ESR) (70 mm/h) and white blood cell (WBC) count (12200 cells/mm3) associated with positive significant level for TPOP146 rubella (IgG 346 UI/mL and IgM 0.8 UI/mL) made possible the initial suspicion of unilateral rubella retinopathy in this case. THSD1 This became reinforced by the salt and pepper fundus appearance of his right eye after two months of initial treatment with prednisone (60 mg for 10 days). His final visual acuity was 20/60 in this eye (Physique 2). == Physique 1. == A) Color photograph of eye fundus before systemic steroid therapyB) fluorescein angiography late phase vasculitis as peripheric lesion. == Physique 2. == A) Color photograph of eye fundus after systemic steroid therapyB) fluorescein angiography late phase vasculitis evolving to salt and pepper lesion. Results analysis also revealed toxoplasma serology IgG 14.2 UI/mL and IgM 0.15 UI/mL. The other exams were normal. A progressive decrease of rubella serology levels (IgG 264.6 UI/mL after one month) and a final level of 184 UI/mL in the second month of follow-up was noticed. == Discussion == Rubella is only found in humans and is transmitted via the respiratory tract. It is generally a moderate TPOP146 disease in children, but may be more severe in adults. It has a maculopapular rash and adults are more likely to experience a prodromal phase with malaise and low-grade fever.4 Rubella is indistinguishable clinically from other infections that present with rash, such as parvovirus B19, measles, human herpesvirus 6 and 7, enterovirus, and group A streptococcus infections.1In tropical countries, like Brazil, dengue should also be considered. In this case, the patient was diagnosed as having rubella. Among all the exams solicited, only the serology for rubella (IgG 346 UI) and for toxoplasmosis (IgG 14.2 UI) were positive and the other exams were negative. The ocular complications of the rubella must be differentiated from other causes of vasculitis and retinitis. Diagnostic assessments to rule out other causes of vasculitis and retinitis were solicited: VDRL, serology for CMV, toxoplasmosis antibodies, HIV, herpes, ESR, chest radiographs, rheumatologic assessments, white blood cells count number, and tuberculin test.5Salt and pepper pigmentary disturbance is a most common ocular complication in congenital rubella but it is not common in adult acquired rubella.6 Because the antibody level to rubella was high during the subacute stage and decreased within two months, we believe this patient had unilateral rubella retinitis, a rare condition not described in adults. We believe this case has several important medical implications to be discussed. First, it demonstrates the necessity to correlate inflammatory ocular findings with previous (or concomitant) systemic diseases, especially viral. Second, it may confirm the possibility of rarely described cases of congenital unilateral rubella retinopathy. Third, it clearly shows the pathogenesis of a salt and pepper retinal appearance originating from a viral-modified previously normal retinal tissue. == Footnotes == Disclosure No conflicts of interest were declared in relation to this paper. == References ==.