Background Cervical cancer can infiltrate locally and directly distributed to adjacent organs including the vagina, peritoneum, urinary bladder, ureters, rectum, and paracervical tissue, but the intestine metastasis from cervical cancer is extremely rare, which can easily be misdiagnosed. sigmoid colon (in (b). Abdominal magnetic resonance (MR) revealed a thickened bowel wall in the terminal ileum (in (c) and upper sigmoid colon (in d). MR imaging also showed an unremarkable uterus stump (in e) Open in a separate window Fig. 2 Colonoscopy and biopsy. Colonoscopy confirmed that the intestinal mucosa was smooth without ulcers or lumps (a) except sigmoid colon luminal narrowing (b). Pathology result of the narrowing site biopsy showed mucosal chronic inflammation (c) The patient was fasted and received passive gastric decompression along with total parenteral nutrition on admission. Abdominal distention eased on the first day. In consideration of the patients condition and the imaging examination and colonoscopy results, exploratory laparotomy was performed. Widespread intestinal adhesion and two firm tumors (2*2?cm and Rabbit Polyclonal to MAK 3*2?cm separately) with a local thickened intestine wall at the end of the ileum and upper sigmoid colon were noted. She underwent segmental intestine AdipoRon ic50 resection and had end-to-end anastomosis. The postoperative pathological diagnosis showed squamous cell carcinoma (Fig.?3). After the operation, up until now (4?months), the patient has been treated with four cycles of the docetaxel-cisplatin mixture chemotherapy routine (day time 1, 75?mg/m2 docetaxel; times 1C3, 25?mg/m2 cisplatin, per 21?times). Open up in another windowpane Fig. 3 Postoperative pathological exam. Microscopic study of the intestinal tumor proven a full-thickness wall structure of sigmoid serosa and digestive tract, as well as the muscular coating from the terminal ileum got metastatic squamous cell carcinoma. Tumor embolus was observed in the vessel, as well as the peri-intestine lymph node had metastatic squamous cell carcinoma also. a little intestine and b sigmoid digestive tract (staining with hematoxylin and eosin, 100 magnification) Dialogue In today’s case, the individual underwent segmental intestine resection, as well as the pathological effect indicated squamous cell carcinoma. Excluding feasible major lesions like oropharynx, nasopharynx, lung, and esophagus tumor, with the features of outside-to-inside invasion through the pathology result, indicating the principal lesion in the abdominal or pelvic cavity, cervical cancer with small intestine and sigmoid colon metastases was diagnosed. After precise calculation, the 10-year incidence of distant metastases was 3?% for stage IA, 16?% for stage AdipoRon ic50 IB, 31?% for stage IIA, 26?% for stage IIB, 39?% for stage III, and 75?% for stage IVA in cervical cancer patients [7]. The most frequently observed metastatic sites were the lungs, bones, liver, supraclavicular nodes, and para-aortic nodes etc. (Table?1). Unusual metastases can be seen in the skin and soft tissues AdipoRon ic50 [8], breast [9], pericardium [10], umbilical region [11], labia and introitus area [12], thyroid gland [13], oral cavity [14], and skeletal muscle [15]. Cervical cancer metastatic to the intestine is a rare occurrence. Table?2 provides a comprehensive review of the published cases of intestine metastases from cervical cancer in the English literature dating back to 1976. Things did not go the way we thought because not only do cervical cancer metastases to the intestine occur at an advanced tumor stage, but they also occur at an early stage, even at stage IA. The case presented here is the first report of cervical cancer with simultaneous small intestine and sigmoid colon metastases. Table 1 The main metastatic sites of cervical cancer not available from original literature The intestine metastases usually occur through the lymphatics to the bowel serosa and less commonly via intraperitoneal dissemination, direct spread, and hematogenous spread [16C18]. As for the present case, another explanation is surgical factor, for tumor dissemination may be caused by reckless operation. Although the possible metastatic route is distinct, the rarity of intestine metastases is still unclear now [19]. Sigmoid colon metastases are rarely seen and may be because of the relatively short intestinal segment. While small intestine accounted for a large space in the enterocelia. So, the low incidence rates of small intestine metastases are.