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Despite reports of effective clinical instances, many tumors appear to resist infection by oncolytic viruses (OVs). are involved in tumor cell immunosurveillance and damage,?tumor illness by an OV may induce immune infiltration to alter the tumor microenvironment.1 For breast cancer, clinical tests are in progress with T-VEC (an engineered herpes virus) (ClinicalTrials.gov: “type”:”clinical-trial”,”attrs”:”text”:”NCT02658812″,”term_id”:”NCT02658812″NCT02658812) and PeXa-VEC

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