The p53 tumor suppressor is an integral proteins in maintaining the integrity from the genome by inducing either cell routine arrest or apoptosis following cellular tension signals. restorative strategy. However, the explanation for advancement of kinase inhibitors that focus BMS-747158-02 IC50 on the Mdm2-Mdmx-p53 axis should be cautiously regarded as since modulation of particular kinase
Background & Goals CD166 (also called activated leukocyte cell adhesion molecule ALCAM) is a marker of colorectal malignancy (CRC) stem cells; it is expressed by aggressive tumors. analyzed. Results CD166 was expressed on the surface of epithelial cells within the stem cell niche and along the length of the intestine; expression was conserved across species.