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Aim: To investigate the protective effects of rhein lysinate (RHL), a major bioactive constituent of the rhizome of rhubarb (Rheum palmatum Linn or Rheum tanguticum Maxim), against kidney impairment in senescence-prone inbred strain 10 (SAMP10) mice. mice with RHL significantly reduced the MAD level, and increased the SOD and GSH-px levels in the kidneys. Glomerulonephritis

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The role of microRNA-155 (miR-155) has been associated with oncogenesis of several AR-C155858 human tumors. targets of miR-155 in a bioinformatics screen. Overexpression of miR-155 downregulated a luciferase transcript AR-C155858 fused to the 3′UTR of JMJD1A and BACH1. MiR-155 mimic could downregulate the expression of JMJD1A and BACH1 while miR-155 inhibitor could AR-C155858 upregulate JMJD1A

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