In Pd-catalyzed C-N cross-coupling reactions α-branched secondary amines are hard IWR-1-endo coupling partners and the desired products are often produced in low yields. of pharmaceutically relevant compounds and biologically active natural products (Number 1).[1] Although Pd-catalyzed carbon-nitrogen (C-N) cross-coupling would provide an efficient means of accessing this valuable class of chemical substances the use of… Continue reading In Pd-catalyzed C-N cross-coupling reactions α-branched secondary amines are hard