We examined the part of microRNAs (miRNAs) in targeting the stromal-derived element 1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Yang 1 (YY1) as a connection between SDF-1α/CXCR4 signaling and allow-7a as YY1 was upregulated by SDF-1α and downregulated by treatment having a CXCR4 antagonist. ChIP assay confirmed the binding of YY1 to unprocessed… Continue reading We examined the part of microRNAs (miRNAs) in targeting the stromal-derived
Tag: Vamp5
The intensity of the BMP signal is determined by cell surface
The intensity of the BMP signal is determined by cell surface receptors that phosphorylate Smad1/5/8 at the C-terminus. axes. The positional information produced by these signal gradients are seamlessly integrated in each individual embryo. A classic example of the self-regulating nature of this patterning integration is demonstrated by cutting a Vamp5 blastula stage embryo in… Continue reading The intensity of the BMP signal is determined by cell surface